Validating test


03-Oct-2019 10:02

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There is commercial statistical software available to support this study.Nevertheless, the determination can easily be performed in a spreadsheet.In contrast to the verification explanation, validation is directly related to the interested parties requirements, such as the accuracy of clinical decision required by the patients.Erroneous binary results, i.e., false results, affect the clinical decision directly.In this sampling, the target population is the set of generic healthy individuals.The number of samples is a limitation to the statistical power of the study. If the number of samples does not affect the fixed percentage directly, its influence is critical to the 95% confidence interval (95% CI).This example also shows the limit of this sampling’s n to the confidence interval - the statistical power of the estimate is poor.CLSI EP12-A2 suggests the study be performed over the course of 10 to 20 days [3]. However, the reproducibility conditions of the study should be assured to reliable estimates.

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The comparison of methods can be determined primarily when the comparator is the diagnostic accuracy criteria, or it can be determined secondarily when the comparator is other than the diagnostic accuracy criteria.

The laboratorian should understand this limitation when defining the specifications.

For instance, the sensitivity confidence interval to n = 5, could not be smaller than 56.6 to 100%.

The validation concepts in this essay only deal with the final binary result that can be applied to any qualitative test. However, the concepts can be applied to any other qualitative test.

Verification and validation definitions are sometimes confusing in practice.

Therefore, the qualitative test validation goal is to confirm, based on data, that the requirements for its use have been fulfilled.